Tsunade is one of the legendary Sannin and the Fifth Hokage of the Hidden Leaf Village in Naruto. As the granddaughter of the First Hokage, Hashirama Senju, she inherited incredible chakra reserves and developed the Strength of a Hundred Seal technique. Her mastery of medical ninjutsu is unparalleled, and she revolutionized the ninja medical corps during her time as Hokage.

Despite her immense power and leadership abilities, Tsunade struggled with personal demons including gambling addiction, fear of blood (stemming from past trauma), and the loss of her loved ones. Her youthful appearance, maintained through a transformation jutsu despite being in her fifties, blonde pigtails, and impressive physique make her instantly recognizable. Under her leadership, Konoha faced numerous threats including the Akatsuki, and she played a crucial role in the Fourth Great Ninja War. Her tough exterior masks a deeply caring nature, especially toward Naruto, whom she comes to view almost as family.